Research in Paroxysmal Nocturnal Hemoglobinuria (PNH)
ACTIVE, NOT RECRUITING
PEGASUS: A Phase 3 study to evaluate the efficacy and safety of pegcetacoplan (APL‑2) in patients with paroxysmal nocturnal hemoglobinuria
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ACTIVE, NOT RECRUITING
PRINCE: A Phase 3, randomized, multicenter, open-label, controlled study to evaluate the efficacy and safety of pegcetacoplan (APL‑2) in patients with PNH
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COMPLETED
PADDOCK: Pilot study to assess safety, preliminary efficacy and pharmacokinetics of subcutaneous pegcetacoplan (APL‑2) in patients with PNH
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ACTIVE, NOT RECRUITING
PALOMINO: A Phase 2a, open-label study to evaluate the efficacy and safety of pegcetacoplan (APL‑2) in patients with PNH who have never been treated with eculizumab
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COMPLETED
PHAROAH: A Phase 1 study to assess the safety of pegcetacoplan (APL‑2) as an add-on to standard of care in patients with PNH
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ENROLLING BY INVITATION
An open-label, nonrandomized, multicenter extension study to evaluate the long term safety and efficacy of pegcetacoplan (APL‑2) in patients with PNH
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Research in Geographic Atrophy (GA)
ACTIVE, NOT RECRUITING
DERBY: A Phase 3 study to evaluate the efficacy and safety of pegcetacoplan (APL-2) in patients with GA secondary to age-related macular degeneration
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ACTIVE, NOT RECRUITING
OAKS: A Phase 3 study to evaluate the efficacy and safety of pegcetacoplan (APL-2) in patients with GA secondary to age-related macular degeneration
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Research in Amyotrophic Lateral Sclerosis (ALS)
ACTIVE, RECRUITING
MERIDIAN: A Phase 2 study evaluating the efficacy and safety of pegcetacoplan in patients with sporadic ALS
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Research in Nephropathies – C3G / IC-MPGN
ACTIVE, RECRUITING
NOBLE: A Phase 2 study evaluating the safety and efficacy of pegcetacoplan in the treatment of post-transplant recurrence C3G or IC-MPGN
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ACTIVE, NOT RECRUITING
DISCOVERY: Phase 2 study assessing safety and efficacy of pegcetacoplan (APL‑2) in glomerulopathies
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Research in Autoimmune Hemolytic Anemia (AIHA)
ACTIVE, NOT RECRUITING
PLAUDIT: A Phase 2, prospective, open-label study to assess the safety, tolerability, preliminary efficacy, pharmacokinetics and pharmacodynamics of multiple doses of pegcetacoplan (APL‑2) in patients with autoimmune hemolytic anemia (AIHA).
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Research in COVID-19
ACTIVE, NOT RECRUITING
COV-201: A Phase 1/2 study evaluating the safety and efficacy of APL-9 in adults with mild to moderate acute respiratory distress syndrome (ARDS) due to COVID-19